USF1 defect drives p53 degradation during <i>Helicobacter pylori</i> infection and accelerates gastric carcinogenesis

Abstract

Our data reveal that the depletion of USF1 and its de-localisation in the vicinity of cell membranes are essential events associated to the genotoxic activity of <i>Hp</i> infection, thus promoting gastric carcinogenesis. These findings are also of clinical relevance, supporting USF1 expression as a potential marker of GC susceptibility.