Concepedia

<p>Triterpenoid Saponins from <em>Anemone flaccida</em> Suppress Tumor Cell Proliferation by Regulating MAPK, PD1/PDL1, and STAT3 Signaling Pathways and Altering Cancer Metabolism</p>

Lintao Han, Shiqi Yao, Sa Cao, Guoyan Mo, Jingjing Li, Yan Cao, Fang Huang

OncoTargets and Therapy · 2019 · 27 citations · 33 references

DOIFull text

Open access

Abstract

The findings suggested that triterpenoid saponins interfered with multiple signaling cascades involved in tumorigenesis and tumor metabolism and have potential applications in HCC therapy.

References

33

Cancer statistics, 2018

Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2018 · 16.8K citations · Full text

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

Gordon J. Freeman, Andrew J. Long, Yoshiko Iwai et al. · The Journal of Experimental Medicine · 2000 · 5.2K citations · Full text

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

Yoshiko Iwai, Masayoshi Ishida, Yoshimasa Tanaka et al. · Proceedings of the National Academy of Sciences · 2002 · 3.1K citations · Full text

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

Yasumasa Ishida, Yasutoshi Agata, Kei‐ichi Shibahara et al. · The EMBO Journal · 1992 · 3.1K citations · Full text

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

David R. Wise, Ralph J. DeBerardinis, Anthony Mancuso et al. · Proceedings of the National Academy of Sciences · 2008 · 1.9K citations · Full text

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