Concepedia

Impaired control of the contact system in hereditary angioedema with normal C1‐inhibitor

Maria Bova, Chiara Suffritti, Valeria Bafunno, Stefania Loffredo, Giorgia Cordisco, Stefano Del Giacco, Tiziana Maria Angela De Pasquale, Davide Firinu, Maurizio Margaglione, Vincenzo Montinaro,

Allergy · 2019 · 38 citations · 47 references

DOIFull text

Open access

Abstract

Our results suggest that pathogenesis of FXII-, ANGPT1-, and U-HAE moves through an unbalanced control of kallikrein activity, with bradykinin as most likely mediator. VEGFs and Ang1 participate in the pathophysiology of U-HAE increasing the basal vascular permeability.

References

47

Hereditary and acquired angioedema: Problems and progress: Proceedings of the third C1 esterase inhibitor deficiency workshop and beyond

A Agostoni, Emel Aygören‐Pürsün, Karen Binkley et al. · Journal of Allergy and Clinical Immunology · 2004 · 640 citations · Full text

Classification, diagnosis, and approach to treatment for angioedema: consensus report from the <scp>H</scp>ereditary <scp>A</scp>ngioedema <scp>I</scp>nternational <scp>W</scp>orking <scp>G</scp>roup

Marco Cicardi, Werner Aberer, Aleena Banerji et al. · Allergy · 2014 · 635 citations · Full text

, , +15

Hereditary angioedema with normal C1-inhibitor activity in women

Konrad Bork, Sven-Erik Barnstedt, Petra Koch et al. · The Lancet · 2000 · 548 citations

, , +6

The international WAO/EAACI guideline for the management of hereditary angioedema—The 2017 revision and update

Marcus Maurer, Markus Magerl, Ignacio J. Ansotegui et al. · Allergy · 2018 · 488 citations · Full text

Hereditary Angioneurotic Edema: Two Genetic Variants

Fred S. Rosen, Patricia Charache, Jack Pensky et al. · Science · 1965 · 439 citations

, , +16