Concepedia

Contact Activation System

Contact Activation System is a coagulation pathway that initiates blood clotting through the sequential activation of factor XII, prekallikrein, and high-molecular-weight kininogen upon exposure to negatively charged surfaces, distinguishing it from the tissue factor-dependent extrinsic pathway.

320

Publications

16.2K

Citations

1.3K

Authors

404

Institutions

Publications per year

2017–2026

50

Parents

Publications

320

Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System

Takashi Kishimoto, Karthik Viswanathan, Tanmoy Ganguly et al. · New England Journal of Medicine · 2008 · 616 citations · Full text

, , +12

beta 2-Glycoprotein I: a plasma inhibitor of the contact activation of the intrinsic blood coagulation pathway

Inger Schousboe · Blood · 1985 · 363 citations · Full text

, , +15

A One-stage Factor VIII (Antihaemophilic Globulin) Assay and its Use on Venous and Capillary Plasma

R. M. Hardisty, Janet C. Macpherson · Thrombosis and Haemostasis · 1962 · 333 citations

, , +14

The contact system contributes to hypotension but not disseminated intravascular coagulation in lethal bacteremia. In vivo use of a monoclonal anti-factor XII antibody to block contact activation in baboons.

Robin A. Pixley, RA De La Cadena, Jimmy D. Page et al. · Journal of Clinical Investigation · 1993 · 278 citations · Full text

, , +16

Crystal Structure of the Catalytic Domain of Human Plasmin Complexed with Streptokinase

Xiaoqiang Wang, Xinli Lin, Jeffrey A. Loy et al. · Science · 1998 · 246 citations

, , +16

1–5 of 320

Authors

1.3K

  1. RW
    Robert W. Colman

    Temple University, United States

    15 publications · 1K citations

    13

    h-index

  2. DG
    David Gailani

    Vanderbilt University, United States

    13 publications · 686 citations

    13

    h-index

  3. HT
    Hugo Ten Cate

    Maastricht University, Netherlands

    9 publications · 408 citations

    9

    h-index

  4. AH
    Alvin H. Schmaier

    University of Michigan, United States

    8 publications · 650 citations

    8

    h-index

  5. BN
    Bonno N. Bouma

    Utrecht University, Netherlands

    8 publications · 628 citations

    8

    h-index

1–5 of 1.3K

Institutions

404

  1. Temple University

    Philadelphia, United States

    16 h-index

    78 publications

    5.7K citations

  2. Dutch Blood Transfusion Society

    Amsterdam, Netherlands

    13 h-index

    41 publications

    2.1K citations

  3. University of Amsterdam

    Amsterdam, The Netherlands

    12 h-index

    48 publications

    2.1K citations

  4. Lund University

    Lund, Sweden

    11 h-index

    39 publications

    2.1K citations

  5. Stony Brook University

    Stony Brook, United States

    8 h-index

    21 publications

    1.1K citations

  6. Aronora (United States)

    Portland, United States

    7 h-index

    24 publications

    1.5K citations

  7. University of Milan

    Milan, Italy

    7 h-index

    16 publications

    779 citations

  8. Humboldt-Universität zu Berlin

    Berlin, Germany

    7 h-index

    16 publications

    564 citations

1–8 of 404

Venues

  1. Thrombosis and Haemostasis

    36 publications · 1.8K citations

    23

    h-index

  2. Blood

    17 publications · 1.6K citations

    15

    h-index

  3. Journal of Biological Chemistry

    JBC · 15 publications · 799 citations

    14

    h-index

  4. Thrombosis Research

    17 publications · 414 citations

    13

    h-index

  5. Blood Coagulation & Fibrinolysis

    12 publications · 420 citations

    12

    h-index

1–5