Protein phosphatase 2A activation as a therapeutic strategy for managing MYC-driven cancers

The landscape of somatic copy-number alteration across human cancers

Rameen Beroukhim, Craig H. Mermel, Dale Porter et al. · Nature · 2010 · 4K citations · Full text

Somatic Variant, Tumor Heterogeneity, Medicine +7

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

Hartmut Land, Luis F. Parada, Robert A. Weinberg · Nature · 1983 · 2.9K citations

Developmental Biology, Tumor Heterogeneity, Least Two +9

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Jake Delmore, Ghayas C. Issa, Madeleine E. Lemieux et al. · Cell · 2011 · 2.8K citations · Full text

Medicine, Immunology, Therapeutic Efficacy +7

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability

Rosalie C. Sears, Faison Nuckolls, Eric B. Haura et al. · Genes & Development · 2000 · 1.4K citations · Full text

Myc Protein Accumulation, Signal Transduction, Cell Regulation +14

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

Veerle Janssens, Jozef Goris · Biochemical Journal · 2001 · 1.4K citations

Molecular Regulation, Cell Growth, Signaling Pathway +17