Concepedia

T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity

Aakanksha Jain, Ricardo A. Irizarry-Caro, Margaret M. McDaniel, Amanpreet Singh Chawla, Kaitlin R. Carroll, Garrett R. Overcast, Naomi H. Philip, Andrew Oberst, Alexander V. Chervonsky, Jonathan D. Katz,

Nature Immunology · 2019 · 94 citations · 35 references

DOIFull text

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Concepts

References

35

The Inflammasome

Fabio Martinon, Kimberly Burns, Jürg Tschopp · Molecular Cell · 2002 · 6K citations · Full text

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nobuhiko Kayagaki, Irma B. Stowe, Bettina L. Lee et al. · Nature · 2015 · 3.7K citations

, , +13

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

Wanting He, Haoqiang Wan, Lichen Hu et al. · Cell Research · 2015 · 2.5K citations · Full text

, , +16

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

Clara P. Manrique, Margaret A Pericak‐Vance, Michelle Lee et al. · Nature Genetics · 2013 · 1.4K citations · Full text

, , +16

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

Lai Wang, Fenghe Du, Xiaodong Wang · Cell · 2008 · 1.4K citations

, , +12