Langerhans Cells Orchestrate the Protective Antiviral Innate Immune Response in the Lymph Node

Eric B. Wong, Brian Montoya, Colby Stotesbury, M C C Ferez, Ren-Huan Xu, Luis J. Sigal

Cell Reports · 2019 · 24 citations · 47 references

DOIFull text

Open access

Concepts

Abstract

DC migration or depletion of LCs, but not DP-DC deficiency, suppresses the IIR in the dLN and results in high viral lethality. Therefore, LCs are the architects of an early IIR in the dLN that is critical for optimal resistance to a disseminating viral infection.

References

47