Discovery of novel 1,2,3-triazole oseltamivir derivatives as potent influenza neuraminidase inhibitors targeting the 430-cavity

The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design

Rupert J. Russell, L.F. Haire, David Stevens et al. · Nature · 2006 · 811 citations

Virus Structure, New Opportunities, Drug Design +11

Computational methods for the prediction of ‘drug-likeness’

David E. Clark, Stephen D. Pickett · Drug Discovery Today · 2000 · 569 citations

Medicine, Computational Biology, Pharmacology +4

Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants

Patrick Collins, L.F. Haire, Yi Pu Lin et al. · Nature · 2008 · 532 citations · Full text

Virus Structure, Molecular Biology, Virology +5

Synthesis of Tamiflu and its Phosphonate Congeners Possessing Potent Anti-Influenza Activity

Jiun‐Jie Shie, Jim‐Min Fang, Shiyun Wang et al. · Journal of the American Chemical Society · 2007 · 199 citations

Medicinal Chemistry, Antiviral Compound, Biochemistry +15

Remarkable Loop Flexibility in Avian Influenza N1 and Its Implications for Antiviral Drug Design

Rommie E. Amaro, David D. L. Minh, Lily S. Cheng et al. · Journal of the American Chemical Society · 2007 · 159 citations

Protein Assembly, Avian Influenza N1, Molecular Biology +21