Acidosis-induced metabolic reprogramming in tumor cells enhances the anti-proliferative activity of the PDK inhibitor dichloroacetate

A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth

Sébastien Bonnet, Stephen L. Archer, Joan Allalunis‐Turner et al. · Cancer Cell · 2007 · 1.5K citations · Full text

Life Sciences, Cancer Biology, Oncology +14

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

Verónica Estrella, Tingan Chen, Mark C. Lloyd et al. · Cancer Research · 2013 · 1.4K citations · Full text

Medicine, Cancer Biology, Oncology +17

Endothelial Nitric Oxide Synthase Targeting to Caveolae

Olivier Féron, Laurent Belhassen, Lester Kobzik et al. · Journal of Biological Chemistry · 1996 · 672 citations · Full text

Life Sciences, Cell Biology, Physiology +14

HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity

Hiroaki Semba, Norihiko Takeda, Takayuki Isagawa et al. · Nature Communications · 2016 · 386 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Induction of Pyruvate Dehydrogenase Kinase-3 by Hypoxia-inducible Factor-1 Promotes Metabolic Switch and Drug Resistance

Chun-Wun Lu, Shih‐Chieh Lin, Ko‐Fan Chen et al. · Journal of Biological Chemistry · 2008 · 340 citations · Full text

Medicine, Cancer Biology, Oncology +17