Bernard Gallez

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

Pierre Sonveaux, Frédérique Végran, Thies Schroeder et al. · Journal of Clinical Investigation · 2008 · 1.6K citations · Full text

Chemoprevention Strategy, Metabolic Remodeling, Cancer Biology +18

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

Massimiliano Mazzone, Daniela Dettori, Rodrigo Leite de Oliveira et al. · Cell · 2009 · 802 citations · Full text

Oncology, Angiogenesis, Medicine +10

A Mitochondrial Switch Promotes Tumor Metastasis

Paolo E. Porporato, Valéry L. Payen, Jhudit Pérez‐Escuredo et al. · Cell Reports · 2014 · 590 citations · Full text

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

Pierre Sonveaux, Tamara Copetti, Christophe J. De Saedeleer et al. · PLoS ONE · 2012 · 511 citations · Full text

Endothelial Cells, Lactate Influx, Metabolic Remodeling +19

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

Julián Aragonés, Martin Schneider, Katie Van Geyte et al. · Nature Genetics · 2008 · 475 citations · Full text

Biochemistry, Redox Regulator, Physiology +9