Concepedia

Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis

Kai Sun, Jiahui Luo, Xingzhi Jing, Jiachao Guo, Xudong Yao, Xiaoxia Hao, Yaping Ye, Shuang Liang, Jiamin Lin, Genchun Wang,

Aging · 2019 · 119 citations · 29 references

DOIFull text

Open access

Abstract

Ast could protect against osteoarthritis via the Nrf2 signaling, suggesting Ast might be a potential therapeutic supplement for OA treatment.

References

29

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the guinea pig

Virginia B. Kraus, Janet L. Huebner, Jeroen DeGroot et al. · Osteoarthritis and Cartilage · 2010 · 1.8K citations · Full text

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The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

S.S. Glasson, M.G. Chambers, W. B. Van Den Berg et al. · Osteoarthritis and Cartilage · 2010 · 1.7K citations · Full text

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Osteoarthritis severity is sex dependent in a surgical mouse model

Tracey Blanchet, Diane Peluso, Bei Hopkins et al. · Osteoarthritis and Cartilage · 2007 · 378 citations

, , +7

Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes

Nazir M. Khan, Abdul Haseeb, Mohammad Y. Ansari et al. · Free Radical Biology and Medicine · 2017 · 285 citations · Full text

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Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappaB activation.

Seon‐Jin Lee, Se Kyung Bai, Kwang Soon Lee et al. · PubMed · 2003 · 278 citations

, , +20