Concepedia

Impaired ATM activation in B cells is associated with bone resorption in rheumatoid arthritis

Kofi A. Mensah, Jeff W. Chen, Jean-Nicolas Schickel, Isabelle Isnardi, Natsuko Yamakawa, Andrea Vega-Loza, Jennifer H. Anolik, Richard A. Gatti, Erwin W. Gelfand, Ruth R. Montgomery,

Science Translational Medicine · 2019 · 29 citations · 48 references

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Abstract

Defective ATM activation skews the B cell repertoire and increases RANKL production, promoting joint erosion in patients with rheumatoid arthritis.

References

48

2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

Daniel Aletaha, Tuhina Neogi, Alan J. Silman et al. · Arthritis & Rheumatism · 2010 · 9.6K citations · Full text

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DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

Emmy P. Rogakou, Duane R. Pilch, Ann H. Orr et al. · Journal of Biological Chemistry · 1998 · 5.4K citations · Full text

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Efficacy of B-Cell–Targeted Therapy with Rituximab in Patients with Rheumatoid Arthritis

Jonathan Edwards, L Szczepański, Jacek Szechiński et al. · New England Journal of Medicine · 2004 · 2.6K citations · Full text

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Predominant Autoantibody Production by Early Human B Cell Precursors

Hedda Wardemann, Sergey Yurasov, Anne Schaefer et al. · Science · 2003 · 2.1K citations

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Human Lymphoid and Myeloid Cell Development in NOD/LtSz- <i>scid IL2R</i> γ <i>null</i> Mice Engrafted with Mobilized Human Hemopoietic Stem Cells,

Leonard D. Shultz, Bonnie Lyons, Lisa Burzenski et al. · The Journal of Immunology · 2005 · 1.7K citations · Full text

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