Research progress of the relationship between pyroptosis and disease.

Abstract

Pyroptosis, characterized by proinflammation, has been defined as a new type of programmed cell death in recent years. Inflammasomes are activated by the corresponding pathogen-associated molecular patterns (PAMPS) or damage-associated molecular patterns (DAMPS), followed up by the cleavage of pro-interleukin-1β (pro-IL-1β), pro-interleukin-18 (pro-IL-18) and gasdermin D. The N-terminal fragment of gasdermin D gives rise to the destruction of cell membrane, leading to cell rupture as well as the efflux of proinflammatory cytokines. Recent studies have shown that pyroptosis is associated with a variety of diseases due to its proinflammation effect and the dysfunction of related cells. The relationship between pyroptosis and associated diseases is described in this review.