Mechanotransduction via the Piezo1-Akt pathway underlies Sost suppression in osteocytes

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

Tomoki Nakashima, Mikihito Hayashi, Takanobu Fukunaga et al. · Nature Medicine · 2011 · 1.7K citations

Medicine, Cell Biology, Physiology +16

Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin

Alexander G. Robling, Paul Niziolek, Lee Ann Baldridge et al. · Journal of Biological Chemistry · 2007 · 1.3K citations · Full text

Natural Sciences, Biochemistry, Molecular Biology +17

Bone Dysplasia Sclerosteosis Results from Loss of the SOST Gene Product, a Novel Cystine Knot–Containing Protein

Mary E. Brunkow, Jessica C. Gardner, Jeff Van Ness et al. · The American Journal of Human Genetics · 2001 · 1K citations · Full text

Medicine, Genetics, Molecular Genetics +11

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

Xiaodong Li, Michael S. Ominsky, Qing‐Tian Niu et al. · Journal of Bone and Mineral Research · 2008 · 938 citations · Full text

Medicine, Genetics, Molecular Genetics +17

Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist

Rutger L. van Bezooijen, Bernard A.J. Roelen, Annemieke Visser et al. · The Journal of Experimental Medicine · 2004 · 883 citations · Full text

Medicine, Biochemistry, Molecular Biology +15