Design, synthesis, insecticidal, and acaricidal activities of novel pyrimidinamine derivatives containing a biphenyl ether

Abstract

Abstract A series of original pyrimidinamine derivatives containing a biphenyl ether moiety were designed and synthesized. Their structures were confirmed by 1 H NMR, MS, and elemental analyses. Their insecticidal activities against lepidopteran and hemiptera insects and acaricidal activities were tested. The results of bioassay demonstrated that 9k showed the best activity (LC 50 = 2.08 mg/L) against Tetranychus urticae , which is comparable with the positive control, spirotetramat (LC 50 = 2.27 mg/L), and 9g showed better activity (LC 50 = 0.52 mg/L) against Aphis fabae than the positive control, imidacloprid (LC 50 = 1.02 mg/L), and relatively good activity (LC 50 = 2.49 mg/L) against T urticae . Their structure‐activity relationships indicated that both an ethyl group on the 4‐position of the pyrimidine ring and alkyl chain as a para‐substituent group of the benzene ring showed good biological activity.