Concepedia

Role of Dehydrocorybulbine in Neuropathic Pain After Spinal Cord Injury Mediated by P2X4 Receptor.

Zhongwei Wang, Qingde Wang, Rundong Guo, Peilin Liu, Yuqiang Wang, Zijuan Zhang, Limin Wang

PubMed · 2019 · 24 citations · 25 references

DOIFull text

Open access

Concepts

Abstract

concentration. Both P2XR and dopamine receptor2 agonists antagonized dehydrocorybulbine's antinociceptive effects. In conclusion, we propose that dehydrocorybulbine produces antinociceptive effects in spinal cord injury models by inhibiting P2X4R.

References

25

P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury

Makoto Tsuda, Yukari Shigemoto‐Mogami, Schuichi Koizumi et al. · Nature · 2003 · 1.5K citations

, , +16

Up-Regulation of P2X<sub>4</sub>Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain

Lauriane Ulmann, Jon P. Hatcher, Jane P. Hughes et al. · Journal of Neuroscience · 2008 · 531 citations · Full text

, , +17

Purinergic Modulation of Interleukin-1β Release from Microglial Cells Stimulated with Bacterial Endotoxin

Davide Ferrari, Paola Chiozzi, Simonetta Falzoni et al. · The Journal of Experimental Medicine · 1997 · 476 citations · Full text

, , +16

The role of microglial P2X7: modulation of cell death and cytokine release

Yingbo He, Natalie Taylor, Lawrence Fourgeaud et al. · Journal of Neuroinflammation · 2017 · 201 citations · Full text

, , +17

P2X<sub>4</sub>Receptors Influence Inflammasome Activation after Spinal Cord Injury

Juan Pablo de Rivero Vaccari, Dominic Bastien, Geoffrey Yurcisin et al. · Journal of Neuroscience · 2012 · 184 citations · Full text

, , +17