Up-Regulation of P2X₄Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain

Lauriane Ulmann, Jon P. Hatcher, Jane P. Hughes, +6

Journal of Neuroscience

The Voltage-Gated Sodium Channel Na _v 1.9 Is an Effector of Peripheral Inflammatory Pain Hypersensitivity

Fumimasa Amaya, Haibin Wang, Michael Costigan, +11

Journal of Neuroscience

The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain

Penny C. Staton, Jon P. Hatcher, Deborah J. Walker, +15

Pain

InflammationCannabis UseAnti-inflammatoryFunctional SelectivityPain Medicine +13

The Selective 5-HT_1BReceptor Inverse Agonist 1‘-Methyl-5-[[2‘-methyl-4‘- (5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-<i>f</i>]indole-3,4‘-piperidine] (SB-224289) Potently Blocks Terminal 5-HT Autoreceptor Function Both in Vitro and in Vivo

Laramie M. Gaster, Frank E. Blaney, Susannah Davies, +18

Journal of Medicinal Chemistry

Enhanced delivery of IL-1 receptor antagonist to the central nervous system as a novel anti–transferrin receptor-IL-1RA fusion reverses neuropathic mechanical hypersensitivity

Carl I. Webster, Jon P. Hatcher, Matthew Burrell, +4

Pain

Activation of the α7-Nicotinic Acetylcholine Receptor Reverses Complete Freund Adjuvant–Induced Mechanical Hyperalgesia in the Rat Via a Central Site of Action

Stephen J. Medhurst, Jon P. Hatcher, Christopher J. Hille, +4

Journal of Pain

Rat ViaHealth SciencesPain MedicineSynaptic TransmissionPhysiology +9

Antibodies binding the head domain of P2X4 inhibit channel function and reverse neuropathic pain

Wendy A. Williams, John E. Linley, Clare A. Jones, +19

Pain

Isolation of blood-brain barrier-crossing antibodies from a phage display library by competitive elution and their ability to penetrate the central nervous system

George Thom, Jon P. Hatcher, Arron Hearn, +5

mAbs

Immunocytochemical TechniqueEngineeringImmunologyCompetitive ElutionBrain Exposure +19

Central inhibition of granulocyte-macrophage colony-stimulating factor is analgesic in experimental neuropathic pain

Louise Nicol, Peter Thornton, Jon P. Hatcher, +8

Pain

A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model

George Thom, Mei-Mei Tian, Jon P. Hatcher, +8

Journal of Cerebral Blood Flow & Metabolism

Pain TherapyPlasma KineticsPain MedicineImmunologyReceptor Antagonist +19