Concepedia

Endothelial SIRT6 blunts stroke size and neurological deficit by preserving blood–brain barrier integrity: a translational study

Luca Liberale, Daniel S. Gaul, Alexander Akhmedov, Nicole R. Bonetti, Vanasa Nageswaran, Sarah Costantino, Jürgen Pahla, Julien Weber, Vera Fehr, Daria Vdovenko,

European Heart Journal · 2019 · 99 citations · 41 references

DOIFull text

Open access

Abstract

Endothelial SIRT6 exerts a protective role in ischaemic stroke by blunting I/R-mediated BBB damage and thus, it may represent an interesting novel therapeutic target to be explored in future clinical investigation.

References

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