Concepedia

Rapid Transduction and Expansion of Transduced T Cells with Maintenance of Central Memory Populations

Mary S. Pampusch, Kumudhini Preethi Haran, Geoffrey T. Hart, Eva G. Rakasz, Aaron Rendahl, Edward A. Berger, Elizabeth Connick, Pamela J. Skinner

Molecular Therapy — Methods & Clinical Development · 2019 · 40 citations · 25 references

DOIFull text

Open access

Concepts

Abstract

cells/kg in a 10 kg rhesus macaque. This 9-day protocol may be broadly used for CAR-T cell and other T cell immunotherapy approaches to decrease culture time and increase maintenance of central memory populations.

References

25

Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias

Renier J. Brentjens, Isabelle Rivière, Jae H. Park et al. · Blood · 2011 · 1.3K citations · Full text

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A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen

Reinhold Förster, Anita E Mattis, Elisabeth Kremmer et al. · Cell · 1996 · 1.1K citations · Full text

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B Cell–attracting Chemokine 1, a Human CXC Chemokine Expressed in Lymphoid Tissues, Selectively Attracts B Lymphocytes via BLR1/CXCR5

Daniel F. Legler, Marcel Loetscher, Regula Stuber Roos et al. · The Journal of Experimental Medicine · 1998 · 850 citations · Full text

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Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells

John Scholler, Troy Brady, Gwendolyn Binder-Scholl et al. · Science Translational Medicine · 2012 · 647 citations · Full text

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Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics

Shannon K. Bromley, Seddon Y. Thomas, Andrew D. Luster · Nature Immunology · 2005 · 500 citations

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