Novel berberine-based derivatives with potent hypoglycemic activity

Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats

Yitong Liu, Haiping Hao, Hong‐Guang Xie et al. · Drug Metabolism and Disposition · 2010 · 339 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Structure Property Relationships of Carboxylic Acid Isosteres

Pierrik Lassalas, Bryant Gay, Caroline Lasfargeas et al. · Journal of Medicinal Chemistry · 2016 · 284 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +17

Effects and mechanisms of berberine in diabetes treatment

Jun Yin, Jianping Ye, Weiping Jia · Acta Pharmaceutica Sinica B · 2012 · 178 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1<i>H</i>-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy

Kimberly O. Cameron, Daniel W. Kung, Amit S. Kalgutkar et al. · Journal of Medicinal Chemistry · 2016 · 117 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Cardiovascular and metabolic effects of Berberine

Flora Affuso · World Journal of Cardiology · 2010 · 91 citations · Full text

Life Sciences, Botany, Pharmacology +14