Concepedia

Nucleoside-modified mRNA encoding HSV-2 glycoproteins C, D, and E prevents clinical and subclinical genital herpes

Sita Awasthi, Lauren M. Hook, Norbert Pardi, Fushan Wang, Arpita Myles, Michael P. Cancro, Gary H. Cohen, Drew Weissman, Harvey M. Friedman

Science Immunology · 2019 · 122 citations · 48 references

DOIFull text

Open access

Concepts

Abstract

T cell responses, and T follicular helper and germinal center B cell responses. The trivalent nucleoside-modified mRNA-LNP vaccine is a promising candidate for human trials.

References

48

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA

Katalin Karikó, Michael Buckstein, Houping Ni et al. · Immunity · 2005 · 2.6K citations · Full text

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HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

Michael R. Betts · Blood · 2006 · 1.8K citations · Full text

, , +14

Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major

Patricia A. Darrah, Dipti T. Patel, Paula Mello De Luca et al. · Nature Medicine · 2007 · 1.4K citations

, , +14

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**

Muthusamy Jayaraman, Steven M. Ansell, Barbara L. Mui et al. · Angewandte Chemie International Edition · 2012 · 1.2K citations · Full text

, , +17

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

Norbert Pardi, Steven Tuyishime, Hiromi Muramatsu et al. · Journal of Controlled Release · 2015 · 1K citations

, , +17