Physicochemical properties of alpha-mangostin loaded nanomeulsions prepared by ultrasonication technique

Abstract

Blank NEs and AMG-NE had droplet size in a range of nanometer and negative value of zeta potential. The droplet size, polydispersity index and zeta potential of blank NEs were affected by formulation compositions and sonication intensities. AMG could be loaded into a representative Blank NE at a maximum concentration of 0.2% w/w and did not cause significant changes in physicochemical properties. AMG-NE showed the antibacterial activity against <i>Staphyloccocus aureus</i> and <i>Propionibacterium acnes</i> without toxicity to the skin cells. Therefore, AMG-NE had potential for using in a clinical study to investigate its efficacy and safety in patients.