Molecules · 2019 · 23 citations · 27 references
Life SciencesImmunologyPharmacologyCell SignalingEthnobotanyInflammationAnti-inflammatory PharmacologyCytokine BiologyInflammatory Cell ResponsesInflammatory MediatorsInflammatory SignalingUltraviolet Radiation BiologyAnti-inflammatory ActivityAnti-inflammatory Natural ProductsAnti-inflammatory ResponseInflammatory Response To RadiationInflammatory Responses To RadiationMonocyte Chemoattractant Protein-1Phenolic CompoundsRadiation-induced Inflammation
Quercus mongolica Fisch. ex Ledeb. (QM) has been used as an oriental traditional medicine to relieve hemorrhoids, fever, and enteritis. We screened the inhibitory activities of the extracts and compounds (1–6) isolated from QM on the production of inflammatory cytokines and chemokines to evaluate their anti-inflammatory activities. Further, we evaluated the expression levels of cytokines, chemokines, and immune factors on pedunculagin (PC, 1), which was selected from isolated compounds (1–6) because of its potential anti-inflammation effect. Additionally, we evaluated whether the inflammation mitigation effects of PC (1) following UVB exposure in keratinocytes occurred because of nuclear factor (NF)-κB and signal transducer and activator of transcription (STAT)/Janus kinase (JAK) activation. PC (1) remarkably suppressed interleukin (IL)-6, IL-10, IL-13, and monocyte chemoattractant protein-1 (MCP-1) mRNA expression and reduced the mRNA expression level of Cyclooxygenase-2 (COX-2) and also reduced the phosphorylation of p38 mitogen-activated protein kinases (p38), c-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinase (ERK) in a concentration-dependent manner.
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Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Zhengui Xia, Martin Dickens, Joël Raingeaud et al. · Science · 1995 · 5.3K citations
Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB
Thomas Henkel, Thomas Machleidt, Irit Alkalay et al. · Nature · 1993 · 1.1K citations