Renoprotective effects of artemisinin and hydroxychloroquine combination therapy on IgA nephropathy via suppressing NF-κB signaling and NLRP3 inflammasome activation by exosomes in rats

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Peter Duewell, Hajime Kono, Katey J. Rayner et al. · Nature · 2010 · 3.9K citations · Full text

Life Sciences, Cell Biology, Immunology +12

High-level semi-synthetic production of the potent antimalarial artemisinin

Christopher J. Paddon, Patrick J. Westfall, Douglas J. Pitera et al. · Nature · 2013 · 2.1K citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA

Le Qu, Jin Ding, Cheng Chen et al. · Cancer Cell · 2016 · 1.2K citations · Full text

Medicine, Molecular Biology, Oncology +16

NLRP3 Gene Silencing Ameliorates Diabetic Cardiomyopathy in a Type 2 Diabetes Rat Model

Beibei Luo, Bo Li, Wenke Wang et al. · PLoS ONE · 2014 · 401 citations · Full text

Life Sciences, Cardiology, Molecular Biology +13

Exosomes derived from hypoxia‐preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice

Guo-hong Cui, Jing Wu, Fang-fang Mou et al. · The FASEB Journal · 2017 · 380 citations

Life Sciences, Neurobiology, Neuroscience +17