Concepedia

Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy

Daniel Moreno-Blas, Elisa Gorostieta-Salas, Alexander Pommer-Alba, Gabriel Muciño-Hernández, Cristian Gerónimo‐Olvera, Luis Ángel Maciel-Barón, Mina Königsberg, Lourdes Massieu, Susana Castro‐Obregón

Aging · 2019 · 140 citations · 42 references

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Abstract

, and autophagy impairment induced cortical cell senescence while autophagy stimulation inhibited it. Our findings suggest that aging-associated dysfunctional autophagy contributes to senescence transition also in neuronal cells.

References

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