Concepedia

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

Florence Debacq‐Chainiaux, Jorge D. Erusalimsky, Judith Campisi, Olivier Toussaint

Nature Protocols · 2009 · 1.6K citations · 28 references

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28

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Goberdhan P. Dimri, X Lee, George Basile et al. · Proceedings of the National Academy of Sciences · 1995 · 7.4K citations · Full text

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Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Jean‐Philippe Coppé · 2008 · 4.1K citations · Full text

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Oxidative stress shortens telomeres

Thomas von Zglinicki · Trends in Biochemical Sciences · 2002 · 2.5K citations

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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

Françis Rodier, Jean‐Philippe Coppé, Christopher K. Patil et al. · Nature Cell Biology · 2009 · 2.2K citations · Full text

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Senescence‐associated β‐galactosidase is lysosomal β‐galactosidase

Bo Yun Lee, Jung A Han, Jun Sub Im et al. · Aging Cell · 2006 · 1.4K citations · Full text

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