Cell Reports · 2019 · 227 citations · 32 references
Life SciencesImmunologyOncologyCancer ImmunologyTumor ImmunologyTumor MicroenvironmentCancer ImmunotherapyChemokine NetworksChemokine SignalingMacrophage BiologyTumor Microenvironment ModulationTumor-associated MacrophagesAdvanced Prostate Cancer TherapyAnti-tumor Macrophage ResponsesC-c Chemokine Receptor 2 SignalingCancer Cell SenescenceCancer-associated MacrophagesInflammation-driven Tumor ProgressionTumor-associated Macrophage RecruitmentTumor-associated Macrophage Reprogramming
mice differentiated in tumor necrosis factor alpha (TNF-α)-releasing pro-inflammatory macrophages, leading to senescence and tumor inhibition. Mechanistically, PTEN-deficient tumor cells are vulnerable to TNF-α-induced senescence, because of an increase of TNFR1. Our results identify TAMs as targets in prostate cancer and describe a therapeutic strategy based on CXCR2 blockade to harness anti-tumorigenic potential of macrophages against this disease.
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