Gedunin Degrades Aggregates of Mutant Huntingtin Protein and Intranuclear Inclusions via the Proteasomal Pathway in Neurons and Fibroblasts from Patients with Huntington’s Disease

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

Marcy E. MacDonald · Cell · 1993 · 8.4K citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

Manish A. Shah, Nicole A. Datson, Lakshmi Srinidhi et al. · Cell · 1993 · 3.1K citations

Life Sciences, Genetics, Molecular Genetics +12

Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

Marian DiFiglia, Ellen Sapp, Kathryn Chase et al. · Science · 1997 · 2.9K citations

Life Sciences, Neurobiology, Neuroscience +16

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

Emma Haapaniemi, Sandeep K. Botla, Jenna Persson et al. · Nature Medicine · 2018 · 1.3K citations · Full text

Life Sciences, Genetics, Molecular Biology +13

p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells

Robert J. Ihry, Kathleen A. Worringer, Max R. Salick et al. · Nature Medicine · 2018 · 1K citations

Life Sciences, Genetics, Molecular Genetics +12