Concepedia

Strategy and validation of a structure-based method for the discovery of selective inhibitors of PAK isoforms and the evaluation of their anti-cancer activity

Peilu Song, Gang Wang, Yuan Su, Hanxun Wang, Jian Wang, Feng Li, Maosheng Cheng

Bioorganic Chemistry · 2019 · 13 citations · 28 references

DOI

Concepts

References

28

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

Edward Manser, Thomas Leung, Harfizah Salihuddin et al. · Nature · 1994 · 1.5K citations

, , +6

Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

Neng Yang, Osamu Higuchi, Kazumasa Ohashi et al. · Nature · 1998 · 1.3K citations

, , +14

Targeting the Intracellular Environment in Cystic Fibrosis: Restoring Autophagy as a Novel Strategy to Circumvent the CFTR Defect

Valeria Rachela Villella, Speranza Esposito, Emanuela M. Bruscia et al. · Frontiers in Pharmacology · 2013 · 388 citations · Full text

, , +17

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

Brion W. Murray, Chuangxing Guo, Joseph Piraino et al. · Proceedings of the National Academy of Sciences · 2010 · 321 citations · Full text

, , +15

Requirement for PAK4 in the Anchorage-independent Growth of Human Cancer Cell Lines

Marinella Callow, Felix Clairvoyant, Shirley Zhu et al. · Journal of Biological Chemistry · 2002 · 307 citations · Full text

, , +16