Concepedia

Endurance Exercise Attenuates Doxorubicin-induced Cardiotoxicity

Youngil Lee, Insu Kwon, Yongchul Jang, Ludmila Cosío-Lima, Patricia J. Barrington

Medicine & Science in Sports & Exercise · 2019 · 48 citations · 33 references

DOI

Abstract

Our data provide novel findings that EXE-induced auto/mitophagy promotion and NOX2 downregulation are linked to cardioprotection against DOX-induced cardiotoxicity. Importantly, our study shows that EXE postconditioning intervention is effective and efficacious to prevent DOX-induced cardiac injuries.

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