Parkin Protein Deficiency Exacerbates Cardiac Injury and Reduces Survival following Myocardial Infarction

Dieter A. Kubli, Xiaoxue Zhang, Youngil Lee, +7

Journal of Biological Chemistry

InflammationProtein Quality ControlReduces SurvivalCardiomyopathyCardiovascular Disease +9

Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes

Youngil Lee, Hwa-Youn Lee, Rita Hanna, +1

American Journal of Physiology-Heart and Circulatory Physiology

MitophagyMitochondrial DysfunctionMolecular BiologyCell DeathMitochondrial Autophagy +16

Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure

Robert L. Thomas, David J. Roberts, Dieter A. Kubli, +7

Genes & Development

Bnip3-mediated mitochondrial autophagy is independent of the mitochondrial permeability transition pore

Melissa N. Quinsay, Robert L. Thomas, Youngil Lee, +1

Autophagy

MitophagyMitochondrial DysfunctionMolecular BiologyCell DeathMitochondrial Autophagy +16

Juvenile Exposure to Anthracyclines Impairs Cardiac Progenitor Cell Function and Vascularization Resulting in Greater Susceptibility to Stress-Induced Myocardial Injury in Adult Mice

Chengqun Huang, Xiaoxue Zhang, Jennifer Ramil, +8

Circulation

Bnip3 functions as a mitochondrial sensor of oxidative stress during myocardial ischemia and reperfusion

Dieter A. Kubli, Melissa N. Quinsay, Chengqun Huang, +2

American Journal of Physiology-Heart and Circulatory Physiology

Caspase-3 Regulation of Diaphragm Myonuclear Domain during Mechanical Ventilation–induced Atrophy

Joseph M. McClung, Andreas N. Kavazis, Keith C. DeRuisseau, +5

American Journal of Respiratory and Critical Care Medicine

Ischemia-reperfusion-induced calpain activation and SERCA2a degradation are attenuated by exercise training and calpain inhibition

Joel P. French, John C. Quindry, Darin J. Falk, +4

American Journal of Physiology-Heart and Circulatory Physiology

Cardiac MuscleHeart FailureMetabolic RemodelingCardiovascular FunctionCalpain Activity +21

Exercise‐induced protection against myocardial apoptosis and necrosis: MnSOD, calcium‐handling proteins, and calpain

Joel P. French, Karyn L. Hamilton, John C. Quindry, +3

The FASEB Journal

Cardiac MuscleManganese Superoxide DismutaseCardiovascular FunctionIr-induced Calpain ActivationCardiovascular Toxicity +21

Cyclophilin D is required for mitochondrial removal by autophagy in cardiac cells

Raquel Carreira, Youngil Lee, Mariam Ghochani, +2

Autophagy

MitophagyHeart FailureCell DeathCyclophilin DCellular Physiology +18