Concepedia

MARK4 (Microtubule Affinity-Regulating Kinase 4)-Dependent Inflammasome Activation Promotes Atherosclerosis—Brief Report

Marc Clément, Xiao Chen, Hannah Chenoweth, Zhongzhao Teng, Sarah Thome, Stephen A. Newland, J. Harrison, Alison Finigan, Ziad Mallat, Xuan Li

Arteriosclerosis Thrombosis and Vascular Biology · 2019 · 25 citations · 12 references

DOIFull text

Open access

Abstract

MARK4-dependent NLRP3 inflammasome activation in the hematopoietic cells regulates the development of atherosclerosis.

References

12

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Paul M. Ridker, Tom Thurén, Jean MacFadyen et al. · New England Journal of Medicine · 2017 · 8.7K citations · Full text

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Peter Duewell, Hajime Kono, Katey J. Rayner et al. · Nature · 2010 · 3.8K citations · Full text

, , +12

Cloning of a new cytokine that induces IFN-γ production by T cells

Haruki Okamura, Hiroko Tsutsui, Toshinori Komatsu et al. · Nature · 1995 · 2.6K citations

, , +10

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

Kristiina Rajamäki, Jani Lappalainen, Katariina Öörni et al. · PLoS ONE · 2010 · 993 citations · Full text

IFN-gamma potentiates atherosclerosis in ApoE knock-out mice.

S Gupta, Ana María Rocandio Pablo, Xinfeng Jiang et al. · Journal of Clinical Investigation · 1997 · 865 citations · Full text

, , +15