Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · 2019 · 222 citations · 18 references
MedicinePharmacologyPharmacotherapyClinical NeuroscienceClinical PharmacologyNeuropharmacologyAmyotrophic Lateral SclerosisNeurodegenerative Disease PharmacologyNeurodegenerative Disease PharmacotherapyNeurodegenerative DiseasesNeurodegenerative DisordersTreatment Response MonitoringAdd-on TherapyDouble-blind TrialsFunctional Decline AssessmentLast Observation Carried ForwardMultiple ImputationPrimary Efficacy EndpointsRiluzole TherapyRiluzole Treatment
Results show that masitinib at 4.5 mg/kg/d can benefit patients with ALS. A confirmatory phase 3 study will be initiated to substantiate these data.
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Comprehensive analysis of kinase inhibitor selectivity
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Projected increase in amyotrophic lateral sclerosis from 2015 to 2040
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Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT
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Medicine, Oncology, Pharmacology +15