Concepedia

Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease

Bryan Zeitler, Steven Froelich, Kimberly Marlen, David A. Shivak, Qi Yu, Davis Li, Jocelynn R. Pearl, Jeffrey C. Miller, Lei Zhang, David E. Paschon,

Nature Medicine · 2019 · 220 citations · 65 references

DOI

Concepts

References

65

On the nature of allosteric transitions: A plausible model

Jacques Monod, Jeffries Wyman, Jean‐Pierre Changeux · Journal of Molecular Biology · 1965 · 8.9K citations

, , +10

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

Marcy E. MacDonald · Cell · 1993 · 8.4K citations · Full text

, , +13

A Third-Generation Lentivirus Vector with a Conditional Packaging System

Tom Dull, Romain Zufferey, Michael T. Kelly et al. · Journal of Virology · 1998 · 3.4K citations · Full text

, , +17

Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice

Laura Mangiarini, Kirupa Sathasivam, Mary J. Seller et al. · Cell · 1996 · 3.1K citations · Full text

, , +17

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

Manish A. Shah, Nicole A. Datson, Lakshmi Srinidhi et al. · Cell · 1993 · 3.1K citations

, , +12