Kirupa Sathasivam

Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice

Laura Mangiarini, Kirupa Sathasivam, Mary J. Seller et al. · Cell · 1996 · 3.1K citations · Full text

Knockout Mouse, Neurodegenerative Diseases, Developmental Biology +9

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

Emma Hockly, Victoria M. Richon, Benjamin Woodman et al. · Proceedings of the National Academy of Sciences · 2003 · 836 citations · Full text

Aberrant splicing of <i>HTT</i> generates the pathogenic exon 1 protein in Huntington disease

Kirupa Sathasivam, Andreas Neueder, Theresa A. Gipson et al. · Proceedings of the National Academy of Sciences · 2013 · 522 citations · Full text

Proteolysis of Mutant Huntingtin Produces an Exon 1 Fragment That Accumulates as an Aggregated Protein in Neuronal Nuclei in Huntington Disease

Christian Landles, Kirupa Sathasivam, Andreas Weiss et al. · Journal of Biological Chemistry · 2010 · 333 citations · Full text

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

Alexandre Kuhn, Daniel R. Goldstein, Angela Hodges et al. · Human Molecular Genetics · 2007 · 321 citations · Full text