Unexpected effect of an hydroxyl group on π-facial selectivity in the nucleophilic addition to bicyclo[2.2.2]octan-2-ones

Chelation or Non‐Chelation Control in Addition Reactions of Chiral α‐ and β‐ Alkoxy Carbonyl Compounds [New Synthetic Methods (44)]

Manfred T. Reetz · Angewandte Chemie International Edition in English · 1984 · 686 citations

Natural Sciences, Chemistry, Inorganic Chemistry +10

Studies in Stereochemistry. XXX. Models for Steric Control of Asymmetric Induction¹

Donald J. Cram, Karl R. Kopecky · Journal of the American Chemical Society · 1959 · 507 citations

Pharmacy, Chemistry, Bioisosterism +10

Structural, mechanistic, and theoretical aspects of chelation-controlled carbonyl addition reactions

Manfred T. Reetz · Accounts of Chemical Research · 1993 · 224 citations

Natural Sciences, Chemistry, Chemical Kinetics +13

Chelates as intermediates in nucleophilic additions to alkoxy ketones according to Cram's rule (cyclic model)

Xiangning Chen, Edwin R. Hortelano, Ernest L. Eliel et al. · Journal of the American Chemical Society · 1992 · 154 citations

Natural Sciences, Biochemistry, Chemistry +10

The structure of vinigrol, a novel diterpenoid with antihypertensive and platelet aggregation-inhibitory activities

Itsuo Uchida, Takeshi Ando, Naoki Fukami et al. · The Journal of Organic Chemistry · 1987 · 72 citations

Medicine, Medicinal Chemistry, Pharmacology +9