Concepedia

One‐pot three‐component synthesis of 2‐substituted 4‐aminoquinazolines

Journal of Heterocyclic Chemistry · 2006 · 27 citations · 18 references

Concepts

Natural SciencesChemistryMedicinal ChemistryOrganic ChemistrySynthetic Medicinal ChemistryHeterocycle SynthesisHeterocyclic ChemistryMicrowave-assisted SynthesisOrganic Synthesis

Abstract

Abstract magnified image A facile and rapid synthesis of the title compounds via one‐pot reaction of 2‐aminobenzonitrile, orthoesters and ammonium acetate under solvent‐free and microwave condition is described.

References

18

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Pelle Lidström, Jason Tierney, Bernard Wathey et al. · Tetrahedron · 2001 · 2.7K citations

Natural Sciences, Chemical Engineering, Chemistry +9

CLINICAL CANCER RESEARCH

D. W. Smithers · The Lancet · 1956 · 1.8K citations

A tentative rationalization of microwave effects in organic synthesis according to the reaction medium, and mechanistic considerations

Laurence Perreux, André Loupy · Tetrahedron · 2001 · 1.3K citations

Natural Sciences, Chemical Engineering, Chemistry +13

Discovery of quinazolines as a novel structural class of potent inhibitors of NF-κB activation

Masanori Tobe, Yoshiaki Isobe, Hideyuki Tomizawa et al. · Bioorganic & Medicinal Chemistry · 2003 · 152 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Microwave-assisted Niementowski reaction. Back to the roots

François-René Alexandre, Amaya Berecibar, Thierry Besson · Tetrahedron Letters · 2002 · 110 citations

Natural Sciences, Chemistry, Catalysis +2