Discovery of quinazolines as a novel structural class of potent inhibitors of NF-κB activation

Masanori Tobe, Yoshiaki Isobe, Hideyuki Tomizawa, +4

Bioorganic & Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryNovel Structural ClassDrug TargetBiochemistry +11

Discovery of 8-Hydroxyadenines as a Novel Type of Interferon Inducer

Kosaku Hirota, Kazunori Kazaoka, Itaru Niimoto, +10

Journal of Medicinal Chemistry

Medicinal ChemistryInterferon InducerPharmaceutical ScienceBiochemistryNatural Sciences +13

Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities

Ayumu Kurimoto, Tetsuhiro Ogino, Shinji Ichii, +7

Bioorganic & Medicinal Chemistry

Pharmaceutical SciencePotent Interferon InducersMedicineImmunology2-Substituted 8-Hydroxyadenines +7

A novel structural class of potent inhibitors of NF-κB activation: structure–activity relationships and biological effects of 6-aminoquinazoline derivatives

Masanori Tobe, Yoshiaki Isobe, Hideyuki Tomizawa, +3

Bioorganic & Medicinal Chemistry

Novel Structural ClassMedicinal Chemistry6-Aminoquinazoline DerivativesBiochemistryMedicine +9

Structure and activity relationships of novel uracil derivatives as topical anti-inflammatory agents

Yoshiaki Isobe, Masanori Tobe, Yoshifumi Inoue, +3

Bioorganic & Medicinal Chemistry

Novel Uracil DerivativesMedicinal ChemistryPharmaceutical ScienceAnti-inflammatoryMedicine +8

Synthesis and structure–activity relationships of phenothiazine carboxylic acids having pyrimidine-dione as novel histamine H1 antagonists

Katsumi Kubota, Hirotaka Kurebayashi, Hirotaka Miyachi, +3

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryDerivative (Chemistry)BiochemistryMedicine +9

Synthesis and Biological Evaluation of Novel 9-Substituted-8-Hydroxyadenine Derivatives as Potent Interferon Inducers

Yoshiaki Isobe, Ayumu Kurimoto, Masanori Tobe, +5

Journal of Medicinal Chemistry

Novel InterferonCompound 9AeImmunologyNovel 9-Substituted-8-hydroxyadenine DerivativesMolecular Biology +14

Synthesis and SAR study of imidazoquinolines as a novel structural class of microsomal prostaglandin E2 synthase-1 inhibitors

Tomoya Shiro, Hirotada Takahashi, Keisuke Kakiguchi, +4

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryNovel Structural ClassMedicinal ChemistryBiochemistryNatural Sciences +7

7-Phenyl-imidazoquinolin-4(5H)-one derivatives as selective and orally available mPGES-1 inhibitors

Tomoya Shiro, Keisuke Kakiguchi, Hirotada Takahashi, +2

Bioorganic & Medicinal Chemistry

Medicinal ChemistryMedicinePharmacological AgentPharmacotherapyDrug Development +4

Synthesis and structure–Activity relationships of 2-Amino-8-hydroxyadenines as orally active interferon inducing agents

Ayumu Kurimoto, Tetsuhiro Ogino, Shinji Ichii, +7

Bioorganic & Medicinal Chemistry

Medicinal ChemistryPharmaceutical ScienceMedicineImmunologyAntiviral Drug Development +7