Photic regulation of peptides located in the ventrolateral subdivision of the suprachiasmatic nucleus of the rat: daily variations of vasoactive intestinal polypeptide, gastrin-releasing peptide, and neuropeptide Y

Kazuyuki Shinohara, Kento Tominaga, Yoshiaki Isobe, +1

Journal of Neuroscience

CryptochromeOptogeneticsGastrointestinal Peptide HormoneDaily VariationsNeuroendocrine Mechanism +23

Discovery of quinazolines as a novel structural class of potent inhibitors of NF-κB activation

Masanori Tobe, Yoshiaki Isobe, Hideyuki Tomizawa, +4

Bioorganic & Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryNovel Structural ClassDrug TargetBiochemistry +11

Crystal Structures and Structure–Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors

Shingo Tojo, Tetsuya Kohno, Tomoyuki Tanaka, +6

ACS Medicinal Chemistry Letters

Drug TargetImidazothiazole DerivativesHeterocycle ChemistryChemical BiologyRedox Biology +17

The Structure and Unusual pH Dependence of Plastocyanin from the Fern Dryopteris crassirhizoma

Takamitsu Kohzuma, Tsuyoshi Inoue, Fuminori Yoshizaki, +9

Journal of Biological Chemistry

Discovery of 8-Hydroxyadenines as a Novel Type of Interferon Inducer

Kosaku Hirota, Kazunori Kazaoka, Itaru Niimoto, +10

Journal of Medicinal Chemistry

Medicinal ChemistryInterferon InducerPharmaceutical ScienceBiochemistryNatural Sciences +13

Increase in neurogenesis and neuroblast migration after a small intracerebral hemorrhage in rats

Tadashi Masuda, Yoshiaki Isobe, Noritaka Aihara, +5

Neuroscience Letters

Cerebral Vascular RegulationNeuroregenerationDevelopmental BiologyNeuroblast MigrationNeuroanatomy +11

Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities

Ayumu Kurimoto, Tetsuhiro Ogino, Shinji Ichii, +7

Bioorganic & Medicinal Chemistry

Pharmaceutical SciencePotent Interferon InducersMedicineImmunology2-Substituted 8-Hydroxyadenines +7

A novel structural class of potent inhibitors of NF-κB activation: structure–activity relationships and biological effects of 6-aminoquinazoline derivatives

Masanori Tobe, Yoshiaki Isobe, Hideyuki Tomizawa, +3

Bioorganic & Medicinal Chemistry

Novel Structural ClassMedicinal Chemistry6-Aminoquinazoline DerivativesBiochemistryMedicine +9

Long-term survival of grafted cells, dopamine synthesis/release, synaptic connections, and functional recovery after transplantation of fetal nigral cells in rats with unilateral 6-OHDA lesions in the nigrostriatal dopamine pathway

Hitoo Nishino, Takeshi Hashitani, Michiko Kumazaki, +6

Brain Research

NeuroregenerationDopamine Synthesis/releaseNeurophysiologyNeuroanatomyNeuropharmacology +9

Structural analysis reveals TLR7 dynamics underlying antagonism

Shingo Tojo, Zhikuan Zhang, Hiroyuki Matsui, +14

Nature Communications