New Conjunctive Reagents as Cross-Coupling Partners En Route to Retinoid-like Polyenes

Abstract

[structure: see text] New conjunctive reagents E-2 and Z-3 can be used, after transmetalation, in Negishi couplings with vinyl and aryl iodides. The subsequently unmasked terminal alkynes can be further manipulated to arrive at retinoid-like products.