Concepedia

Synthesis of trifluoromethylated [1,4]diazepines from 1,1,1-trifluoroalk-3-yn-2-ones

Alexey R. Romanov, Alexander Yu. Rulev, Igor A. Ushakov, Vasiliy M. Muzalevskiy, Valentine G. Nenajdenko

Mendeleev Communications · 2014 · 24 citations · 14 references

DOI

Concepts

Abstract

The target heterocycles are formed under mild conditions in good yields and with high selectivity.

References

14

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw et al. · Journal of Medicinal Chemistry · 1997 · 2K citations · Full text

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Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor

Vincent J. Merluzzi, Karl D. Hargrave, Mark E. Labadia et al. · Science · 1990 · 746 citations

, , +17

Mixing with microwaves: solvent-free and catalyst-free synthesis of pyrazoles and diazepines

Buchi Reddy Vaddula, Rajender S. Varma, John Leazer · Tetrahedron Letters · 2013 · 81 citations

, , +12

Synthesis and biological activity of novel calcium channel blockers: 2,5-dihydro-4-methyl-2-phenyl-1,5-benzothiazepine-3-carboxylic acid esters and 2,5-dihydro-4-methyl-2-phenyl-1,5-benzodiazepine-3-carboxylic acid esters

Karnail S. Atwal, James L. Bergey, Anders Hedberg et al. · Journal of Medicinal Chemistry · 1987 · 75 citations · Full text

, , +11

Synthesis of 2-Phenylazonaphtho[1,8-ef][1,4]diazepines and 9-(3-Arylhydrazono)pyrrolo[1,2-a]perimidines as Antitumor Agents

Thoraya A. Farghaly, Eman M. H. Abbas, Kamal M. Dawood et al. · Molecules · 2014 · 41 citations · Full text

, , +6