Analysis of complexes of inhibitors with Cryptosporidium hominis DHFR leads to a new trimethoprim derivative

QXP: Powerful, rapid computer algorithms for structure-based drug design

Colin McMartin, Regine S. Bohacek · Journal of Computer-Aided Molecular Design · 1997 · 511 citations

Insights into antifolate resistance from malarial DHFR-TS structures

Jirundon Yuvaniyama, P. Chitnumsub, Sumalee Kamchonwongpaisan et al. · Nature Structural & Molecular Biology · 2003 · 402 citations · Full text

Biochemistry, Antifolate Resistance, Medicine +5

Target Guided Synthesis of 5-Benzyl-2,4-diamonopyrimidines: Their Antimalarial Activities and Binding Affinities to Wild Type and Mutant Dihydrofolate Reductases from <i>Plasmodium falciparum</i>

Chawanee Sirichaiwat, Chakapong Intaraudom, Sumalee Kamchonwongpaisan et al. · Journal of Medicinal Chemistry · 2003 · 88 citations · Full text

Antiparasitic Agent, Malaria, Plasmodium Falciparum +16

The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 å resolution

JN Champness, A. Achari, S. Ballantine et al. · Structure · 1994 · 87 citations · Full text

Biosynthesis, Aldo-keto Reductase, Biochemistry +5

Phylogenetic Classification of Protozoa Based on the Structure of the Linker Domain in the Bifunctional Enzyme, Dihydrofolate Reductase-Thymidylate Synthase

Robert H. O’Neil, Ryan Lilien, Bruce R. Donald et al. · Journal of Biological Chemistry · 2003 · 70 citations · Full text