Opportunities for enzyme catalysis in natural product chemistry

Production of the antimalarial drug precursor artemisinic acid in engineered yeast

Dae‐Kyun Ro, Eric M. Paradise, Mario Ouellet et al. · Nature · 2006 · 2.8K citations

Life Sciences, Biological Engineering, Biotechnology +12

High-level semi-synthetic production of the potent antimalarial artemisinin

Christopher J. Paddon, Patrick J. Westfall, Douglas J. Pitera et al. · Nature · 2013 · 2.1K citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Engineering a mevalonate pathway in Escherichia coli for production of terpenoids

Vincent J. J. Martin, Douglas J. Pitera, Sydnor T. Withers et al. · Nature Biotechnology · 2003 · 1.7K citations

Life Sciences, Biotechnology, Microbiology +14

Asymmetric Catalysis with Water: Efficient Kinetic Resolution of Terminal Epoxides by Means of Catalytic Hydrolysis

Makoto Tokunaga, Jay F. Larrow, Fumitoshi Kakiuchi et al. · Science · 1997 · 1.4K citations

Natural Sciences, Chemical Engineering, Chemistry +17

Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis

Jonathan Kennedy, Karine Auclair, Steven G. Kendrew et al. · Science · 1999 · 660 citations

Life Sciences, Biochemistry, Enzymology +16