Cerebral Cavernous Malformations Develop Through Clonal Expansion of Mutant Endothelial Cells

Abstract

This is the first study to visualize, with single-cell resolution, the clonal expansion of mutant ECs within CCMs. The incorporation of wild-type ECs into the growing malformation presents another series of cellular events whose elucidation would enhance our understanding of CCMs and may provide novel therapeutic opportunities.