EI-1941-1 and -2, Novel Interleukin-1.BETA. Converting Enzyme Inhibitors Produced by Farrowia sp. E-1941: II. Taxonomy of Producing Strain, Fermentation, Isolation, Physico-chemical Properties, and Biological Properties

Abstract

EI-1941-1 and -2, novel interleukin-1 beta converting enzyme (ICE) inhibitors, were isolated from the culture broths of Farrowia sp. E-1941. EI-1941-1 and -2 selectively inhibited the human recombinant ICE activity with IC50 values of 0.086 and 0.006 microM, respectively. Taxonomy and fermentation of the producing strain and isolation, physico-chemical properties, structure elucidation, and biological properties of EI-1941-1 and -2 are described.