Concepedia

Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity

Carsten Spanka, Ralf Glatthar, Sandrine Desrayaud, Markus Fendt, David Orain, Thomas Troxler, Ivo Vranesic

Bioorganic & Medicinal Chemistry Letters · 2009 · 32 citations · 22 references

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References

22

A simple and reliable conflict procedure for testing anti-anxiety agents

John R. Vogel, Bernard Beer, Donald E. Clody · Psychopharmacology · 1971 · 846 citations

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2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

F. Gasparini, Kurt Lingenhöhl, Natacha Stoehr et al. · Neuropharmacology · 1999 · 720 citations

, , +7

Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain

Carmelo Romano, Michael A. Sesma, Colin T. McDonald et al. · The Journal of Comparative Neurology · 1995 · 673 citations

, , +15

Conditioned fear as revealed by magnitude of startle response to an auditory stimulus.

Judson S. Brown, Harry I. Kalish, Ilya Farber · Journal of Experimental Psychology · 1951 · 651 citations

, , +14

Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice

Cristiano Chiamulera, Mark P. Epping-Jordan, Alessandro Zocchi et al. · Nature Neuroscience · 2001 · 549 citations

, , +14