Group 4 Metals in Polyketide Synthesis: A Convergent Strategy for the Synthesis of Polypropionate-derived (<i>E</i>,<i>E</i>)-Trisubstituted 1,3-Dienes

Abstract

[reaction: see text] A convergent Group 4 metal-mediated coupling process is described for the synthesis of polypropionate-derived (E,E)-1,3-dienes. Both the stereochemistry of the internal alkyne and the presence/absence of a tethered alkoxide on this pi-component were found to play critical roles in dictating the regiochemical course of these reactions.