Journal of Heterocyclic Chemistry · 1998 · 40 citations · 21 references
MedicineMedicinal ChemistryPharmacologyDrug DiscoveryMolecular PharmacologyStructure-activity RelationshipsEnzyme InhibitionPlatelet ActivationPlatelet AggregationPlatelet FunctionPlatelet PhysiologyAggregation InhibitorsPlatelet Aggregation InhibitionPlatelet InhibitionPyridazine Chemistry
Abstract Several 3(2 H )‐pyridazinones with amino groups at the 5‐position of the pyridazine nucleus have been prepared. The 6‐aryl‐5‐halo‐3(2 H )‐pyridazinones obtained from mucochloric and mucobromic acid lead to the corresponding 5‐alkylamino‐3(2 H )‐pyridazinones, which were tested as platelet aggregation inhibitors.
21
Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal
G. V. R. Born · Nature · 1962 · 4.3K citations
Medicine, Biochemistry, Hematology +14
James A. Bristol, Ila Sircar, Walter H. Moos et al. · Journal of Medicinal Chemistry · 1984 · 151 citations · Full text
Medicine, Cardiology, Pharmacology +11