Role of Platelet Microparticles in Blood Diseases: Future Clinical Perspectives.

Abstract

Platelet microparticles (PMPs) are released from the resting or activated platelet membrane, which includes a variety of proteins, mRNA, miRNA, lipids, and other substances. PMPs are involved in cell communication in vivo and are potential markers for multiple diseases. This narrative review focuses on the extraction, identification, and intercellular role of PMPs, with emphasis on the lesser known aspects of PMPs, namely, PMPs and complement systems, and their role in some diseases and disorders of women such as miscarriage and polycystic ovary syndrome, as well as the application of proteomics. For clinical purposes, we should first consider the importance of PMPs quantification and then what treatment should be given in response to increased quantities of PMPs as observed in many diseases. Currently, methods for quantification of PMPs are still in the experimental stages. Proteomics testing will expand biomarker discovery as well as future PMPs diagnostic and therapeutic applications.