Translating Cell and Gene Biopharmaceutical Products for Health and Market Impact. Product Scaling From Clinical to Marketplace: Lessons Learned and Future Outlook

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

Michael Kalos, Bruce L. Levine, David L. Porter et al. · Science Translational Medicine · 2011 · 2.4K citations · Full text

Life Sciences, Immunology, Oncology +17

Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

Marco Ruella, Jun Xu, David M. Barrett et al. · Nature Medicine · 2018 · 645 citations · Full text

Life Sciences, Immunology, Oncology +12

Clinical Pharmacology of Tisagenlecleucel in B-cell Acute Lymphoblastic Leukemia

Karen Thudium Mueller, Edward Waldron, Stephan A. Grupp et al. · Clinical Cancer Research · 2018 · 222 citations · Full text

Pharmacy, Clinical Pharmacokinetics, Pharmacology +17

Sipuleucel-T (provenge) injection: the first immunotherapy agent (vaccine) for hormone-refractory prostate cancer.

Enock Anassi, Uche Anadu Ndefo · PubMed · 2011 · 154 citations · Full text

Medicine, Surgery, Urology +16

Good Manufacturing Practices (GMP) manufacturing of advanced therapy medicinal products: a novel tailored model for optimizing performance and estimating costs

Mohamed Abou‐El‐Enein, Andy Römhild, Daniel R. Kaiser et al. · Cytotherapy · 2013 · 84 citations

Engineering, Manufacturing Engineering, Pharmacoeconomics +16